nurs6521 week 11 discussion
Discussion: Off-Label Drug Use in Pediatrics
The unapproved use of approved drugs, also called off-label
use, with children is quite common. This is because pediatric dosage guidelines
are typically unavailable since very few drugs have been specifically
researched and tested with children.
When treating children, prescribers often adjust dosages
approved for adults to accommodate a child’s weight. However, children are not
just “smaller” adults. Adults and children process and respond to drugs
differently in their absorption, distribution, metabolism, and excretion.
Children even respond differently during stages from infancy to adolescence.
This poses potential safety concerns when prescribing drugs to pediatric
patients. As an advanced practice nurse, you have to be aware of safety
implications of the off-label use of drugs with this patient group.
Review the Bazzano et al. and Mayhew articles in the
Learning Resources. Reflect on situations in which children should be
prescribed drugs for off-label use.
Think about strategies to make the off-label use and dosage
of drugs safer for children from infancy to adolescence. Consider specific
off-label drugs that you think require extra care and attention when used in
With these thoughts in mind:
By Day 3
Post an explanation of circumstances under which children
should be prescribed drugs for off-label use. Then, describe strategies to make
the off-label use and dosage of drugs safer for children from infancy to
adolescence. Include descriptions and names of off-label drugs that require
extra care and attention when used in pediatrics.
By Day 6
Read a selection of your colleagues’ responses and respond
to at least two of your colleagues on two different days who provided a
different rationale than you did, in one or more of the following ways:
Offer and support an alternative perspective using readings
from the classroom or from your own research in the Walden Library.
Validate an idea with your own experience and additional